HitPredict

Interactor 1: NFL (P07196)
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)
Gene: NEFL

Interactor 2: NECD (Q99608)
Necdin
Gene: NDN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26871637, 24722188, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 321
+	Mm
		440261 NFL_MOUSE (1-543): 1.57e-148: 439: 93.93		NECD_MOUSE (1-321): 2.12e-119: 348: 82.15
+	Hs
		443749 VIME_HUMAN (34-402): 6.74e-84: 270: 49.59		NECD_HUMAN (1-321): 7.79e-122: 354: 100.00
+	Hs
		531620 K2C5_HUMAN (56-403): 3.13e-64: 221: 31.62		NECD_HUMAN (1-321): 7.79e-122: 354: 100.00
+	Hs
		380514 K2C6B_HUMAN (56-419): 8.8e-64: 220: 30.79		NECD_HUMAN (1-321): 7.79e-122: 354: 100.00
+	Hs
		443680 VIME_HUMAN (34-402): 6.74e-84: 270: 49.59		MAGE2_HUMAN (59-310): 2.54e-64: 213: 28.57
+	Hs
		111193 I6L9F6_HUMAN (219-376): 2.5e-29: 119: 61.01		NECD_HUMAN (1-321): 7.79e-122: 354: 100.00
+	Hs
		1055222 KRT81_HUMAN (238-543): 2.15e-09: 61.8: 13.29		NECD_HUMAN (1-321): 7.79e-122: 354: 100.00