HitPredict

Interactor 1: PROS (P07225)
Vitamin K-dependent protein S
Gene: PROS1

Interactor 2: BMP4 (P12644)
Bone morphogenetic protein 4 (BMP-4) (Bone morphogenetic protein 2B) (BMP-2B)
Gene: BMP4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 676 Hs			1 408
+	Hs
		351256 TENX_HUMAN (2-281): 7.15e-29: 126: 13.10		TGFB1_HUMAN (47-407): 5.81e-81: 255: 21.45
+	Hs
		351461 FBLN5_HUMAN (94-240): 6.06e-26: 113: 27.39		TGFB1_HUMAN (47-407): 5.81e-81: 255: 21.45
+	Hs
		901974 FBLN3_HUMAN (94-240): 3.16e-21: 99.4: 22.58		TGFB2_HUMAN (52-407): 1e-84: 266: 22.08
+	Hs
		351363 FBLN3_HUMAN (94-240): 3.16e-21: 99.4: 22.58		TGFB1_HUMAN (47-407): 5.81e-81: 255: 21.45
+	Hs
		155758 GAS6_HUMAN (3-163): 9.98e-17: 86.1: 15.53		GDF8_HUMAN (41-407): 2.05e-83: 261: 21.01
+	Mm
		380164 LTBP3_MOUSE (157-288): 1.99e-13: 76.3: 32.61		TGFB1_MOUSE (47-407): 2.1e-86: 269: 21.81
+	Hs
		312875 FBLN5_HUMAN (94-240): 6.06e-26: 113: 27.39		GDF11_HUMAN (46-407): 1.52e-71: 232: 21.60
+	Hs
		724335 FBN1_HUMAN (90-231): 1.32e-11: 70.6: 24.83		TGFB2_HUMAN (52-407): 1e-84: 266: 22.08
+	Hs
		351456 LTBP3_HUMAN (119-267): 1.68e-11: 69.7: 33.94		TGFB1_HUMAN (47-407): 5.81e-81: 255: 21.45
+	Hs
		155770 CELR1_HUMAN (237-379): 4.59e-09: 62.2: 8.73		GDF8_HUMAN (41-407): 2.05e-83: 261: 21.01
+	Hs
		351380 LTBP1_HUMAN (119-241): 7.07e-09: 61.3: 29.20		TGFB1_HUMAN (47-407): 5.81e-81: 255: 21.45
+	Hs
		885357 CELR1_HUMAN (237-379): 4.59e-09: 62.2: 8.73		INHBE_HUMAN (24-407): 1.44e-67: 219: 24.17