HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.793

The method score is based on:

Property Details
Experiments 25416956, 24549644
Identification Methods two hybrid, affinity chromatography technology, x-ray crystallography
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Thioredoxin~Thioredoxin, Thioredoxin~Thioredoxin_6, Thioredoxin_6~Thioredoxin_6
Common GO terms GO:0003723 - RNA binding
GO:0003756 - protein disulfide isomerase activity
GO:0003779 - actin binding
GO:0004656 - procollagen-proline 4-dioxygenase activity
GO:0005178 - integrin binding
and 32 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 508
Hs

1 508
+ Hs
+ Dm
+ Sc
+ Sc
+ Hs
+ Hs
+ Mm
+ Ce
+ Hs
+ Hs
+ Mm
+ Dm
+ Hs
+ Nc
+ Hs
+ Mm

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Last updated: 15 Jul 2024