HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006888 - endoplasmic reticulum to Golgi vesicle-mediated transport GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 768
+	Hs
		671809 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		423223 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1024120 PDIA2_HUMAN (380-507): 1.39e-25: 111: 26.52		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041984 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041612 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1043092 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043446 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1041083 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1041391 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1040990 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		1220448 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		1067782 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		CUL5_HUMAN (25-768): 0: 597: 23.77