HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: EDEM1 (Q92611)
ER degradation-enhancing alpha-mannosidase-like protein 1
Gene: EDEM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 32423001
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 657
+	Hs
		1268001 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		EDEM1_HUMAN (1-657): 0: 971: 100.00
+	Hs
		531924 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		EDEM1_HUMAN (1-657): 0: 971: 100.00
+	Hs
		1220441 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		EDEM1_HUMAN (1-657): 0: 971: 100.00
+	Hs
		423344 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		EDEM2_HUMAN (97-619): 0: 599: 39.35
+	Hs
		423351 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		EDEM3_HUMAN (84-586): 0: 584: 41.80
+	Hs
		671915 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		EDEM3_HUMAN (84-586): 0: 584: 41.80
+	Sc
		572779 PDI_YEAST (21-482): 4.03e-89: 284: 28.15		MNL1_YEAST (122-591): 3.51e-176: 523: 39.92
+	Sc
		690739 EUG1_YEAST (2-508): 4.03e-84: 271: 21.46		MNL1_YEAST (122-591): 3.51e-176: 523: 39.92
+	Hs
		1310894 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		EDEM3_HUMAN (84-586): 0: 584: 41.80
+	Hs
		531974 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		EDEM3_HUMAN (84-586): 0: 584: 41.80
+	Hs
		1220461 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		EDEM3_HUMAN (84-586): 0: 584: 41.80