HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29509190, 25604459
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019899 - enzyme binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 530
+	Hs
		368827 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369055 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		423142 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		1067778 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369960 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369639 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		320213 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		377332 PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64