HitPredict

Interactor 1: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Interactor 2: THIOM (Q99757)
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)
Gene: TXN2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	31018154
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Thioredoxin~Thioredoxin, Thioredoxin~Thioredoxin_6
Common GO terms	GO:0015035 - protein-disulfide reductase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 508 Hs			1 166
+	Hs
		423123 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		PDIA4_HUMAN (60-165): 8.06e-30: 115: 26.61
+	Hs
		423107 PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00		PDIA1_HUMAN (27-163): 6.3e-29: 112: 21.99
+	Dm
		870451 PDI_DROME (2-477): 3.62e-130: 389: 54.93		THIO2_DROME (61-162): 1.96e-36: 123: 36.89
+	Dm
		870452 PDI_DROME (2-477): 3.62e-130: 389: 54.93		PDIA6_DROME (62-153): 7.11e-29: 111: 24.73
+	Hs
		671722 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		PDIA3_HUMAN (30-163): 7.89e-34: 125: 19.57
+	Hs
		671819 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		PDIA6_HUMAN (62-165): 2.26e-33: 123: 23.81
+	Hs
		531739 PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57		PDIA4_HUMAN (60-165): 8.06e-30: 115: 26.61
+	At
		1226367 PDI11_ARATH (2-476): 3.34e-107: 330: 33.95		TRXY2_ARATH (1-165): 2.9e-41: 137: 23.03
+	At
		1114800 PDI11_ARATH (2-476): 3.34e-107: 330: 33.95		TRXH3_ARATH (77-155): 3.38e-14: 67: 39.24
+	Mm
		956780 ERP44_MOUSE (372-494): 5.48e-24: 105: 18.61		THIOM_MOUSE (1-166): 1.21e-53: 169: 88.55
+	Ce
		1089129 PDI1_CAEEL (365-493): 1.03e-25: 111: 25.76		PDI2_CAEEL (28-162): 1.09e-31: 120: 21.74
+	Mm
		1265749 ERP44_MOUSE (372-494): 5.48e-24: 105: 18.61		PDIA6_MOUSE (62-165): 7.26e-34: 125: 22.86
+	Mm
		653446 ERP44_MOUSE (372-494): 5.48e-24: 105: 18.61		PDIA3_MOUSE (30-163): 2.21e-33: 124: 19.57
+	Hs
		531837 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		PDIA6_HUMAN (62-165): 2.26e-33: 123: 23.81
+	Mm
		1265101 ERP44_MOUSE (372-494): 5.48e-24: 105: 18.61		TXND5_MOUSE (41-165): 2.62e-30: 115: 21.71
+	Hs
		531910 PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22		TXND5_HUMAN (82-165): 3.12e-30: 115: 31.82
+	Hs
		531966 ERP44_HUMAN (363-494): 1.8e-23: 104: 17.39		PDIA4_HUMAN (60-165): 8.06e-30: 115: 26.61
+	Hs
		423286 DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38		PDIA1_HUMAN (27-163): 6.3e-29: 112: 21.99