HitPredict

Interactor 1: KLK3 (P07288)
Prostate-specific antigen (PSA) (EC 3.4.21.77) (Gamma-seminoprotein) (Seminin) (Kallikrein-3) (P-30 antigen) (Semenogelase)
Gene: KLK3

Interactor 2: FRAS1 (Q86XX4)
Extracellular matrix organizing protein FRAS1 (Fraser syndrome 1 protein)
Gene: FRAS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 261 Hs			1 4008
+	Hs
		1204963 KLK11_HUMAN (22-260): 1.51e-105: 309: 40.17		FRAS1_HUMAN (1-4008): 0: 2806: 100.00
+	Hs
		1204970 KLK5_HUMAN (8-260): 5.42e-94: 280: 40.00		FRAS1_HUMAN (1-4008): 0: 2806: 100.00
+	Hs
		621376 CMA1_HUMAN (25-260): 9.9e-40: 139: 38.12		FRAS1_HUMAN (1-4008): 0: 2806: 100.00
+	Hs
		1132306 KLK5_HUMAN (8-260): 5.42e-94: 280: 40.00		FREM2_HUMAN (1296-3338): 2.12e-108: 393: 18.62
+	Hs
		621371 CMA1_HUMAN (25-260): 9.9e-40: 139: 38.12		FREM2_HUMAN (1296-3338): 2.12e-108: 393: 18.62
+	Hs
		428693 TRY1_HUMAN (4-260): 2.96e-114: 329: 40.47		AGRV1_HUMAN (1121-3205): 1.27e-35: 153: 12.28
+	Hs
		980580 KLK5_HUMAN (8-260): 5.42e-94: 280: 40.00		NOTC2_HUMAN (567-1139): 7.18e-39: 163: 13.53
+	Hs
		589592 KLK2_HUMAN (1-261): 1.16e-119: 344: 77.01		PCSK6_HUMAN (314-564): 3.29e-18: 94.9: 20.90
+	Hs
		420738 KLK1_HUMAN (1-260): 7.96e-116: 334: 60.54		PCSK6_HUMAN (314-564): 3.29e-18: 94.9: 20.90
+	Hs
		420758 KLK1_HUMAN (1-260): 7.96e-116: 334: 60.54		CHRD_HUMAN (90-280): 6.28e-15: 84.3: 32.11
+	Hs
		1055020 KLK11_HUMAN (22-260): 1.51e-105: 309: 40.17		FAT1_HUMAN (208-422): 2.76e-12: 75.8: 10.19
+	Hs
		664192 KLK15_HUMAN (15-260): 1e-96: 285: 39.45		PCSK6_HUMAN (314-564): 3.29e-18: 94.9: 20.90
+	Hs
		664194 TMPS4_HUMAN (7-256): 4.1e-90: 275: 29.77		PCSK6_HUMAN (314-564): 3.29e-18: 94.9: 20.90
+	Hs
		1329627 KLK15_HUMAN (15-260): 1e-96: 285: 39.45		CELR2_HUMAN (985-1093): 1.37e-10: 70.4: 16.36
+	Hs
		1055016 TMPS4_HUMAN (7-256): 4.1e-90: 275: 29.77		FAT1_HUMAN (208-422): 2.76e-12: 75.8: 10.19
+	Hs
		1329632 KLK15_HUMAN (15-260): 1e-96: 285: 39.45		CELR1_HUMAN (213-451): 3.32e-09: 65.8: 12.20
+	Hs
		1336516 KLK5_HUMAN (8-260): 5.42e-94: 280: 40.00		CELR2_HUMAN (985-1093): 1.37e-10: 70.4: 16.36
+	Hs
		621379 CMA1_HUMAN (25-260): 9.9e-40: 139: 38.12		AGRV1_HUMAN (1121-3205): 1.27e-35: 153: 12.28
+	Hs
		621366 CMA1_HUMAN (25-260): 9.9e-40: 139: 38.12		FAT1_HUMAN (208-422): 2.76e-12: 75.8: 10.19
+	Hs
		621373 CMA1_HUMAN (25-260): 9.9e-40: 139: 38.12		FAT4_HUMAN (2-88): 4.91e-10: 68.5: 9.89