HitPredict

Interactor 1: H10 (P07305)
Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed]
Gene: H1-0

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	16365885, 17361108, 17224799, 12970441, 12949733, 12800980, 12383116, 16985050, 19829063, 15147269, 18719096
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 194 Hs			1 298
+	Mm
		501126 H10_MOUSE (1-194): 6.74e-33: 118: 94.85		CDK2_MOUSE (1-298): 1.06e-157: 445: 85.26
+	Xl
		612080 H10A_XENLA (7-194): 2.71e-24: 96.3: 64.74		CDK2_XENLA (1-296): 8.04e-162: 453: 89.53
+	Mm
		501119 H10_MOUSE (1-194): 6.74e-33: 118: 94.85		CDK1_MOUSE (1-289): 8.74e-143: 405: 66.21
+	Hs
		414681 H10_HUMAN (1-194): 8.19e-31: 112: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Mm
		501122 H10_MOUSE (1-194): 6.74e-33: 118: 94.85		CDK5_MOUSE (1-292): 1.87e-138: 394: 59.39
+	Hs
		426619 H10_HUMAN (1-194): 8.19e-31: 112: 100.00		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Xl
		612081 H10A_XENLA (7-194): 2.71e-24: 96.3: 64.74		CDK1A_XENLA (1-291): 1.26e-143: 407: 67.12
+	Hs
		426604 H10_HUMAN (1-194): 8.19e-31: 112: 100.00		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00