HitPredict

Interactor 1: FES (P07332)
Tyrosine-protein kinase Fes/Fps (EC 2.7.10.2) (Feline sarcoma/Fujinami avian sarcoma oncogene homolog) (Proto-oncogene c-Fes) (Proto-oncogene c-Fps) (p93c-fes)
Gene: FES

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8916957
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PI3K_P85_iSH2~SH2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 724
+	Hs
		561382 FER_HUMAN (1-820): 0: 874: 50.30		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		561399 FER_HUMAN (1-820): 0: 874: 50.30		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		69202 A9UF07_HUMAN (368-820): 6.11e-157: 502: 32.35		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		561393 FER_HUMAN (1-820): 0: 874: 50.30		RHG21_HUMAN (78-531): 1.19e-59: 221: 13.46
+	Hs
		655254 ABL2_HUMAN (368-817): 2.56e-160: 499: 32.70		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		337356 ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		561401 FER_HUMAN (1-820): 0: 874: 50.30		RHG23_HUMAN (40-369): 2.83e-52: 198: 16.80
+	Hs
		655277 BLK_HUMAN (365-818): 4.82e-159: 474: 30.72		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		442782 HCK_HUMAN (335-817): 1.75e-156: 468: 29.16		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		69198 A9UF07_HUMAN (368-820): 6.11e-157: 502: 32.35		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129151 ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129173 HCK_HUMAN (335-817): 1.75e-156: 468: 29.16		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129232 TEC_HUMAN (325-821): 7.35e-154: 465: 28.17		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		789082 ABL2_HUMAN (368-817): 2.56e-160: 499: 32.70		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		846504 BLK_HUMAN (365-818): 4.82e-159: 474: 30.72		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		442864 HCK_HUMAN (335-817): 1.75e-156: 468: 29.16		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		337492 ABL1_HUMAN (368-820): 1.22e-152: 477: 32.35		RHG17_HUMAN (41-350): 6.97e-54: 201: 18.50
+	Ce
		220207 SRC2_CAEEL (400-817): 1.13e-157: 470: 32.35		TG325_CAEEL (127-273): 1.97e-41: 164: 27.70
+	Hs
		433222 FGR_HUMAN (399-816): 3.46e-159: 475: 31.83		YES_HUMAN (568-724): 2.15e-31: 131: 20.61
+	Hs
		433215 YES_HUMAN (399-816): 2.3e-154: 464: 33.41		YES_HUMAN (568-724): 2.15e-31: 131: 20.61