HitPredict

Interactor 1: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	11847211, 10025673, 7782294, 10648820, 11850825
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019221 - cytokine-mediated signaling pathway GO:0043066 - negative regulation of apoptotic process GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 972 Hs			1 906
+	Mm
		452178 CSF1R_MOUSE (1-972): 0: 726: 74.57		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		499234 KIT_HUMAN (16-956): 0: 609: 37.13		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		452353 PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		557035 PGFRA_HUMAN (1-910): 7.32e-178: 547: 31.95		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610268 FLT3_HUMAN (29-945): 6.56e-178: 545: 31.35		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		404008 PGFRB_MOUSE (22-967): 1.54e-176: 544: 31.64		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		499262 KIT_HUMAN (16-956): 0: 609: 37.13		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Hs
		452407 PGFRB_HUMAN (22-967): 5.22e-180: 553: 31.31		CBLB_HUMAN (23-901): 0: 793: 46.65
+	Rn
		88770 RET_RAT (564-946): 3.5e-74: 267: 39.43		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		572586 VGFR1_HUMAN (21-507): 3.44e-46: 182: 15.58		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		610553 VGFR1_MOUSE (3-507): 4.06e-53: 204: 17.44		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		601457 FGFR2_HUMAN (32-209): 3.68e-27: 121: 15.53		CBL_HUMAN (1-906): 0: 917: 100.00
+	Rn
		88773 VGFR1_RAT (3-560): 2.33e-51: 199: 15.82		D3ZV15_RAT (1-883): 0: 833: 89.00
+	Hs
		610252 UFO_HUMAN (1-308): 2.37e-23: 108: 14.49		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		607879 FGFR4_HUMAN (32-215): 6.05e-23: 107: 15.71		CBL_HUMAN (1-906): 0: 917: 100.00
+	Mm
		403532 KIT_MOUSE (9-293): 5.75e-23: 107: 13.08		CBL_MOUSE (1-906): 0: 888: 91.59
+	Hs
		203204 FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		508077 FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56		MICA3_HUMAN (406-905): 3.1e-14: 79.6: 11.67
+	Hs
		508152 FGFR1_HUMAN (32-209): 4.95e-24: 110: 14.56		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Rn
		94375 FGFR1_RAT (32-209): 1.21e-24: 112: 14.56		F1M9G7_RAT (544-894): 3.04e-09: 63.4: 11.58