Interactor 1: CAN1 (P07384)
Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
Gene: CAPN1

Interactor 2: CAN2 (P17655)
Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)
Gene: CAPN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Calpain_III~EF-hand_8, Calpain_III~Peptidase_C2, EF-hand_8~EF-hand_8, Peptidase_C2~Peptidase_C2
Common GO terms GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005829 - cytosol
and 5 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 714
Hs

1 700
+ Hs
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+ Dm
+ Dm
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+ Rn
+ Zm
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Last updated: 15 Jul 2024