HitPredict

Interactor 1: TBB5 (P07437)
Tubulin beta chain (Tubulin beta-5 chain)
Gene: TUBB

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	30581152, 33961781, 32814053
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0044877 - protein-containing complex binding GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 444 Hs			1 440
+	Hs
		933789 TBB4B_HUMAN (1-427): 0: 707: 98.36		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1036564 TBB2A_HUMAN (1-430): 0: 704: 96.98		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		319824 TBB3_HUMAN (1-444): 0: 712: 92.57		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		319791 TBB4B_HUMAN (1-427): 0: 707: 98.36		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		319992 TBB6_HUMAN (1-432): 0: 703: 92.13		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		428212 TBB5_HUMAN (1-429): 0: 709: 100.00		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78