HitPredict

Interactor 1: TBB5 (P07437)
Tubulin beta chain (Tubulin beta-5 chain)
Gene: TUBB

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	35563538, 21145461, 37207277
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome and 1 others more... GO:0072686 - mitotic spindle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 444 Hs			1 768
+	Hs
		1037217 TBB3_HUMAN (1-444): 0: 712: 92.57		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042440 TBB2B_HUMAN (1-430): 0: 707: 97.44		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		933797 TBB4B_HUMAN (1-427): 0: 707: 98.36		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1041535 TBB2A_HUMAN (1-430): 0: 704: 96.98		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042432 TBB6_HUMAN (1-432): 0: 703: 92.13		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		428194 TBB5_HUMAN (1-429): 0: 709: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		933798 TBB4B_HUMAN (1-427): 0: 707: 98.36		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		1043198 TBB6_HUMAN (1-432): 0: 703: 92.13		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		428195 TBB5_HUMAN (1-429): 0: 709: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		933799 TBB4B_HUMAN (1-427): 0: 707: 98.36		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		1037216 TBB3_HUMAN (1-444): 0: 712: 92.57		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		428191 TBB5_HUMAN (1-429): 0: 709: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		933795 TBB4B_HUMAN (1-427): 0: 707: 98.36		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		381195 TBB4A_HUMAN (1-427): 0: 702: 97.42		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		428192 TBB5_HUMAN (1-429): 0: 709: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		933796 TBB4B_HUMAN (1-427): 0: 707: 98.36		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1041313 TBB2A_HUMAN (1-430): 0: 704: 96.98		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		1037340 TBB3_HUMAN (1-444): 0: 712: 92.57		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		428348 TBB5_HUMAN (1-429): 0: 709: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Hs
		933919 TBB4B_HUMAN (1-427): 0: 707: 98.36		CUL5_HUMAN (25-768): 0: 597: 23.77