HitPredict

Interactor 1: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Interactor 2: GNAI3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)
Gene: GNAI3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23798571
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~G-alpha
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0007188 - adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0016020 - membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 413 Hs			1 354
+	Hs
		429011 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAI1_HUMAN (1-354): 4.65e-179: 502: 93.79
+	Hs
		391305 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92
+	Hs
		428911 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAT2_HUMAN (1-354): 3.7e-167: 471: 69.49
+	Hs
		429010 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		GNAS2_HUMAN (1-353): 1.44e-139: 403: 38.68
+	Hs
		450979 OPRM_HUMAN (5-381): 1.32e-67: 221: 20.57		GNAO_HUMAN (1-354): 6.89e-171: 481: 71.27
+	Hs
		580402 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNAZ_HUMAN (1-353): 7.65e-156: 443: 67.23
+	Hs
		602214 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNA13_HUMAN (2-353): 2.06e-152: 435: 38.33
+	Hs
		602211 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNAS2_HUMAN (1-353): 1.44e-139: 403: 38.68
+	Hs
		391310 ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36		GNAI2_HUMAN (1-354): 2.82e-174: 489: 85.92
+	Hs
		445801 ADA2A_HUMAN (3-229): 5.19e-38: 144: 36.36		GNAO_HUMAN (1-354): 6.89e-171: 481: 71.27
+	Hs
		602212 DRD5_HUMAN (50-348): 3.24e-80: 256: 34.04		GNA12_HUMAN (19-350): 4.26e-86: 266: 42.14