HitPredict

Interactor 1: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	24561123
Identification Methods	protein complementation assay, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043410 - positive regulation of MAPK cascade GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 413 Hs			1 236
+	Hs
		428955 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		TSN7_HUMAN (1-234): 7.1e-56: 180: 22.31
+	Hs
		428918 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		722930 ADA1A_HUMAN (12-352): 1.19e-80: 257: 30.73		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		887838 5HT4R_HUMAN (30-398): 7.08e-80: 252: 32.90		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		783912 5HT4R_HUMAN (30-398): 7.08e-80: 252: 32.90		TSN7_HUMAN (1-234): 7.1e-56: 180: 22.31
+	Hs
		208446 OX2R_HUMAN (2-374): 2.75e-79: 253: 21.62		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		326031 NK3R_HUMAN (1-411): 1.34e-70: 231: 21.26		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		326025 NK1R_HUMAN (9-412): 1.37e-69: 227: 21.12		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		237787 NK1R_HUMAN (9-412): 1.37e-69: 227: 21.12		TSN3_HUMAN (4-236): 1.19e-43: 149: 18.88
+	Hs
		326029 AA2BR_HUMAN (38-368): 1.1e-35: 135: 30.88		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48