HitPredict

Interactor 1: ADRB2 (P07550)
Beta-2 adrenergic receptor (Beta-2 adrenoreceptor) (Beta-2 adrenoceptor)
Gene: ADRB2

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	9671706, 23798571
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 413 Hs			1 337
+	Hs
		153858 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		429068 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15
+	Mm
		578603 ADRB2_MOUSE (1-413): 2.74e-118: 352: 87.08		MAGI3_MOUSE (14-296): 5.46e-17: 84.2: 18.47
+	Rn
		495779 ADRB2_RAT (1-413): 1.35e-117: 350: 87.32		DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48
+	Hs
		429106 ADRB2_HUMAN (1-413): 1.07e-122: 363: 100.00		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		441654 ADRB1_HUMAN (2-361): 1.1e-86: 273: 49.75		MAGI2_HUMAN (3-192): 5.72e-19: 90: 17.19
+	Hs
		441653 ADRB1_HUMAN (2-361): 1.1e-86: 273: 49.75		MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15
+	Hs
		441656 ADRB1_HUMAN (2-361): 1.1e-86: 273: 49.75		MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95
+	Hs
		441650 ADRB1_HUMAN (2-361): 1.1e-86: 273: 49.75		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Rn
		574798 ADRB1_RAT (50-413): 1.34e-82: 262: 47.96		MAGI3_RAT (14-296): 3.3e-16: 81.9: 18.15
+	Hs
		626682 ADA1D_HUMAN (2-405): 8.28e-81: 261: 29.34		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		626687 ADA1D_HUMAN (2-405): 8.28e-81: 261: 29.34		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		600726 DRD1_HUMAN (11-347): 5.07e-80: 255: 33.99		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		676818 SSR2_MOUSE (1-372): 4.66e-79: 250: 22.87		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Rn
		677498 SSR4_RAT (5-345): 6.91e-78: 247: 23.99		DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48
+	Mm
		830268 SSR4_MOUSE (7-345): 2.97e-75: 241: 23.19		DLG2_MOUSE (79-232): 1.54e-14: 76.5: 18.63
+	Mm
		830267 SSR4_MOUSE (7-345): 2.97e-75: 241: 23.19		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		676813 SSR1_MOUSE (4-344): 1.12e-74: 239: 24.27		DLG2_MOUSE (79-232): 1.54e-14: 76.5: 18.63
+	Mm
		676812 SSR1_MOUSE (4-344): 1.12e-74: 239: 24.27		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		722923 SSR5_HUMAN (4-383): 8.34e-77: 244: 21.88		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45