HitPredict

Interactor 1: SEC4 (P07560)
Ras-related protein SEC4 (Suppressor of RHO3 protein 6)
Gene: SEC4

Interactor 2: RAEP (P32864)
Rab proteins geranylgeranyltransferase component A (Rab escort protein) (REP)
Gene: MRS6

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.80	0.794

Property	Details
Experiments	10893259, 26918858, 18467557, 22615397
Identification Methods	affinity chromatography technology, protein complementation assay, dihydrofolate reductase reconstruction
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	GDI~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Sc			1 603
+	Sc
		350859 YPT1_YEAST (13-215): 2.85e-85: 252: 46.60		RAEP_YEAST (1-603): 0: 843: 100.00
+	Hs
		678340 RAB10_HUMAN (15-215): 6.71e-91: 266: 54.19		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Hs
		838619 RAB10_HUMAN (15-215): 6.71e-91: 266: 54.19		GDIB_HUMAN (45-434): 6.79e-174: 502: 26.26
+	Hs
		678381 RAB8B_HUMAN (13-211): 6.81e-85: 252: 54.00		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Hs
		678344 RAB1A_HUMAN (10-215): 3.47e-83: 247: 49.28		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Mm
		838709 RAB1A_MOUSE (10-215): 3.47e-83: 247: 49.28		GDIA_MOUSE (45-434): 2.77e-176: 508: 25.76
+	Hs
		838673 RAB8B_HUMAN (13-211): 6.81e-85: 252: 54.00		GDIB_HUMAN (45-434): 6.79e-174: 502: 26.26
+	Hs
		678343 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		GDIA_HUMAN (45-434): 1.03e-176: 509: 26.01
+	Hs
		838625 RAB1A_HUMAN (10-215): 3.47e-83: 247: 49.28		GDIB_HUMAN (45-434): 6.79e-174: 502: 26.26
+	Hs
		838624 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		GDIB_HUMAN (45-434): 6.79e-174: 502: 26.26
+	Sc
		350882 YPT1_YEAST (13-215): 2.85e-85: 252: 46.60		GDI1_YEAST (45-433): 5.5e-154: 451: 24.18
+	Sc
		429208 SEC4_YEAST (1-215): 6.97e-82: 244: 100.00		GDI1_YEAST (45-433): 5.5e-154: 451: 24.18
+	Hs
		622573 RAB10_HUMAN (15-215): 6.71e-91: 266: 54.19		RAE1_HUMAN (44-104): 3.13e-17: 87.5: 39.34
+	Hs
		642720 RAB10_HUMAN (15-215): 6.71e-91: 266: 54.19		RAE2_HUMAN (44-103): 9.72e-17: 85.9: 41.67
+	Hs
		622608 RAB8B_HUMAN (13-211): 6.81e-85: 252: 54.00		RAE1_HUMAN (44-104): 3.13e-17: 87.5: 39.34
+	Hs
		642738 RAB8B_HUMAN (13-211): 6.81e-85: 252: 54.00		RAE2_HUMAN (44-103): 9.72e-17: 85.9: 41.67
+	Hs
		622577 RAB1A_HUMAN (10-215): 3.47e-83: 247: 49.28		RAE1_HUMAN (44-104): 3.13e-17: 87.5: 39.34
+	Hs
		642723 RAB1A_HUMAN (10-215): 3.47e-83: 247: 49.28		RAE2_HUMAN (44-103): 9.72e-17: 85.9: 41.67
+	Hs
		622576 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		RAE1_HUMAN (44-104): 3.13e-17: 87.5: 39.34
+	Hs
		642722 RB11A_HUMAN (10-215): 5.54e-82: 244: 39.44		RAE2_HUMAN (44-103): 9.72e-17: 85.9: 41.67