HitPredict - High confidence protein-protein interactions

Interactor 1: SAP (P07602)
Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]
Gene: PSAP

Interactor 2: SAP (P07602)
Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]
Gene: PSAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.790

Property	Details
Experiments	12518053, 18462685
Identification Methods	x-ray crystallography, molecular sieving, cosedimentation in solution
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	SapB_1~SapB_1, SapB_1~SapB_2, SapB_2~SapB_2
Common GO terms	GO:0002020 - protease binding GO:0005543 - phospholipid binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0005764 - lysosome and 25 others more... GO:0005765 - lysosomal membrane GO:0005770 - late endosome GO:0005886 - plasma membrane GO:0006665 - sphingolipid metabolic process GO:0007041 - lysosomal transport GO:0007193 - adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway GO:0008047 - enzyme activator activity GO:0010506 - regulation of autophagy GO:0019216 - regulation of lipid metabolic process GO:0035577 - azurophil granule membrane GO:0042803 - protein homodimerization activity GO:0043202 - lysosomal lumen GO:0043231 - intracellular membrane-bounded organelle GO:0060736 - prostate gland growth GO:0060742 - epithelial cell differentiation involved in prostate gland development GO:0062023 - collagen-containing extracellular matrix GO:0070062 - extracellular exosome GO:0097110 - scaffold protein binding GO:1903771 - positive regulation of beta-galactosidase activity GO:1905572 - ganglioside GM1 transport to membrane GO:1905573 - ganglioside GM1 binding GO:1905574 - ganglioside GM2 binding GO:1905575 - ganglioside GM3 binding GO:1905576 - ganglioside GT1b binding GO:1905577 - ganglioside GP1c binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	524
Hs

1	524

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Last updated: 15 Jul 2024