HitPredict

Interactor 1: CATL1 (P07711)
Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]
Gene: CTSL

Interactor 2: CATK (P43235)
Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X)
Gene: CTSK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.811

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Inhibitor_I29~Inhibitor_I29, Inhibitor_I29~Peptidase_C1, Peptidase_C1~Peptidase_C1
Common GO terms GO:0001968 - fibronectin binding
GO:0004197 - cysteine-type endopeptidase activity
GO:0005518 - collagen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 13 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 333
Hs

1 329
+ Hs
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+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024