HitPredict

Interactor 1: CATL1 (P07711)
Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain]
Gene: CTSL

Interactor 2: CYTM (Q15828)
Cystatin-M (Cystatin-6) (Cystatin-E)
Gene: CST6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cystatin~Peptidase_C1
Common GO terms	GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 333 Hs			1 149
+	Hs
		245811 CATL2_HUMAN (1-333): 1.72e-170: 478: 77.25		CYTM_HUMAN (1-149): 6.28e-53: 166: 100.00
+	Hs
		344922 CATL1_HUMAN (1-333): 5.35e-176: 492: 100.00		CYTN_HUMAN (26-148): 1.05e-44: 145: 29.84
+	Hs
		344815 CATL1_HUMAN (1-333): 5.35e-176: 492: 100.00		CYTC_HUMAN (23-148): 1.44e-43: 142: 33.07
+	Hs
		245770 CATL2_HUMAN (1-333): 1.72e-170: 478: 77.25		CYTN_HUMAN (26-148): 1.05e-44: 145: 29.84
+	Hs
		245769 CATL2_HUMAN (1-333): 1.72e-170: 478: 77.25		CYTC_HUMAN (23-148): 1.44e-43: 142: 33.07
+	Hs
		283668 CATL1_HUMAN (1-333): 5.35e-176: 492: 100.00		CYTF_HUMAN (14-146): 6.48e-38: 128: 29.58
+	Hs
		345171 CATL1_HUMAN (1-333): 5.35e-176: 492: 100.00		KNG1_HUMAN (17-112): 1.1e-12: 66.1: 18.75
+	Hs
		637215 CATS_HUMAN (1-333): 5.17e-142: 406: 47.77		CYTD_HUMAN (7-149): 1.32e-43: 142: 25.52
+	Hs
		245772 CATL2_HUMAN (1-333): 1.72e-170: 478: 77.25		KNG1_HUMAN (17-112): 1.1e-12: 66.1: 18.75
+	Hs
		344926 CATH_HUMAN (2-332): 6.44e-128: 370: 37.28		CYTN_HUMAN (26-148): 1.05e-44: 145: 29.84
+	Hs
		344817 CATH_HUMAN (2-332): 6.44e-128: 370: 37.28		CYTC_HUMAN (23-148): 1.44e-43: 142: 33.07
+	Hs
		453952 CATH_HUMAN (2-332): 6.44e-128: 370: 37.28		CYTD_HUMAN (7-149): 1.32e-43: 142: 25.52
+	Hs
		345173 CATH_HUMAN (2-332): 6.44e-128: 370: 37.28		KNG1_HUMAN (17-112): 1.1e-12: 66.1: 18.75