HitPredict

Interactor 1: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Interactor 2: ARP2 (P61160)
Actin-related protein 2 (Actin-like protein 2)
Gene: ACTR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Profilin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 394
+	Bt
		361199 PROF1_BOVIN (1-140): 3.82e-78: 229: 95.00		ACTB_BOVIN (1-388): 0: 574: 46.65
+	Hs
		430115 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ACTB_HUMAN (1-388): 0: 574: 46.65
+	Hs
		430128 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ACTG_HUMAN (3-388): 0: 573: 46.37
+	Mm
		892155 PROF1_MOUSE (1-140): 5.37e-77: 226: 95.71		ACTB_MOUSE (1-388): 0: 574: 46.65
+	Bt
		361200 PROF1_BOVIN (1-140): 3.82e-78: 229: 95.00		ACTS_BOVIN (2-388): 0: 569: 46.51
+	Hs
		430130 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ACTC_HUMAN (2-388): 0: 569: 46.51
+	Hs
		430125 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ACTA_HUMAN (3-388): 0: 567: 45.86
+	Hs
		714946 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		ACTB_HUMAN (1-388): 0: 574: 46.65
+	Mm
		892215 PROF2_MOUSE (1-140): 9.83e-75: 220: 61.43		ACTB_MOUSE (1-388): 0: 574: 46.65
+	Hs
		714953 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		ACTG_HUMAN (3-388): 0: 573: 46.37
+	Hs
		714954 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		ACTC_HUMAN (2-388): 0: 569: 46.51
+	Hs
		714951 PROF2_HUMAN (1-140): 1.13e-74: 220: 61.43		ACTA_HUMAN (3-388): 0: 567: 45.86
+	Hs
		891639 PROF3_HUMAN (1-139): 5.72e-65: 195: 43.17		ACTB_HUMAN (1-388): 0: 574: 46.65
+	Hs
		891641 PROF3_HUMAN (1-139): 5.72e-65: 195: 43.17		ACTC_HUMAN (2-388): 0: 569: 46.51
+	Hs
		891640 PROF3_HUMAN (1-139): 5.72e-65: 195: 43.17		ACTA_HUMAN (3-388): 0: 567: 45.86