HitPredict

Interactor 1: CD3E (P07766)
T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
Gene: CD3E

Interactor 2: ZAP70 (P43403)
Tyrosine-protein kinase ZAP-70 (EC 2.7.10.2) (70 kDa zeta-chain associated protein) (Syk-related tyrosine kinase)
Gene: ZAP70

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

The method score is based on:

Property	Details
Experiments	7761456, 8647168, 8906806, 11855827
Identification Methods	pull down, affinity chromatography technology, surface plasmon resonance
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001772 - immunological synapse GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway and 7 others more... GO:0019722 - calcium-mediated signaling GO:0042101 - T cell receptor complex GO:0042110 - T cell activation GO:0045059 - positive thymic T cell selection GO:0045060 - negative thymic T cell selection GO:0050850 - positive regulation of calcium-mediated signaling GO:0050852 - T cell receptor signaling pathway
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	207
Hs

1	619

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024