HitPredict

Interactor 1: CDC4 (P07834)
Cell division control protein 4 (E3 ubiquitin ligase complex SCF subunit CDC4) (F-box protein CDC4)
Gene: CDC4

Interactor 2: HST4 (P53688)
NAD-dependent histone deacetylase HST4 (EC 2.3.1.286) (Homologous to SIR2 protein 4) (Regulatory protein SIR2 homolog 4)
Gene: HST4

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	16338374, 24389104
Identification Methods	unspecified method, enzymatic study, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 779 Sc			1 370
+	Sc
		431144 CDC4_YEAST (1-779): 0: 553: 100.00		HST3_YEAST (67-370): 2.4e-93: 287: 31.40
+	Hs
		1281302 FBXW7_HUMAN (449-777): 4.6e-67: 237: 21.18		SIR1_HUMAN (12-370): 5.92e-73: 242: 21.80
+	Hs
		1016300 TBL3_HUMAN (393-777): 1.41e-47: 183: 13.90		SIR6_HUMAN (60-370): 1.77e-70: 226: 21.54
+	Hs
		1016333 TBL3_HUMAN (393-777): 1.41e-47: 183: 13.90		SIR7_HUMAN (13-370): 2.01e-64: 212: 18.87
+	Mm
		1257535 FZR1_MOUSE (385-668): 1.96e-34: 139: 14.42		SIR2_MOUSE (90-365): 2.16e-77: 245: 22.48
+	Hs
		1220785 FZR1_HUMAN (385-680): 3.82e-35: 142: 14.50		SIR2_HUMAN (90-365): 3.62e-75: 239: 21.14
+	Hs
		1220786 FBW1A_HUMAN (603-777): 1.43e-28: 123: 13.89		SIR2_HUMAN (90-365): 3.62e-75: 239: 21.14
+	Hs
		1344499 NLE1_HUMAN (696-778): 7.17e-16: 83.2: 16.47		SIR7_HUMAN (13-370): 2.01e-64: 212: 18.87