HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: RET (P07949)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0009410 - response to xenobiotic stimulus GO:0043025 - neuronal cell body GO:0045793 - positive regulation of cell size
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1114
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (501-1061): 2.81e-150: 471: 32.61
+	Hs
		431871 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB4_HUMAN (433-1087): 1.1e-143: 467: 23.43
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (501-1061): 4.63e-147: 462: 33.16
+	Hs
		337788 HS90A_HUMAN (1-732): 0: 1087: 100.00		EGFR_HUMAN (428-1113): 5.86e-141: 457: 23.24
+	Rn
		948941 HS90A_RAT (1-732): 0: 1085: 97.95		Q9QX70_RAT (426-1113): 1.3e-141: 459: 23.07
+	Hs
		383537 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB2_HUMAN (428-1113): 6.03e-140: 456: 24.93
+	Hs
		431596 HS90A_HUMAN (1-732): 0: 1087: 100.00		VGFR2_HUMAN (344-1105): 2.13e-137: 451: 23.91
+	Hs
		384111 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK1_HUMAN (383-1018): 3.43e-142: 449: 23.69
+	Rn
		948940 HS90A_RAT (1-732): 0: 1085: 97.95		Q8K3F9_RAT (428-1113): 7.79e-134: 439: 24.10
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (396-1018): 1.21e-135: 434: 25.28
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (396-1018): 1.21e-135: 434: 25.28
+	Hs
		431901 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK2_HUMAN (590-1018): 1.26e-124: 403: 30.74
+	Hs
		431534 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR4_HUMAN (535-1054): 4.33e-124: 401: 37.89
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (604-1031): 2.72e-110: 369: 28.51
+	Hs
		431892 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK3_HUMAN (638-1020): 2.11e-106: 355: 31.19
+	Hs
		87585 HS90B_HUMAN (19-732): 0: 1059: 86.13		C9JYL6_HUMAN (506-664): 2.25e-113: 350: 98.74
+	Hs
		431595 HS90A_HUMAN (1-732): 0: 1087: 100.00		VGFR3_HUMAN (677-1012): 1.84e-76: 278: 41.25
+	Hs
		426974 HS90A_HUMAN (1-732): 0: 1087: 100.00		CSF1R_HUMAN (706-1018): 4.91e-74: 267: 40.22
+	Hs
		431600 HS90A_HUMAN (1-732): 0: 1087: 100.00		FLT3_HUMAN (714-1014): 2.21e-72: 262: 40.00
+	Hs
		431591 HS90A_HUMAN (1-732): 0: 1087: 100.00		TIE1_HUMAN (693-1019): 5.88e-71: 260: 44.24