HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: MET (P08581)
Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)
Gene: MET

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26517842, 21325980
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0009986 - cell surface GO:0016020 - membrane and 1 others more... GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1390
+	Hs
		437816 HS90B_HUMAN (19-732): 0: 1059: 86.13		MET_HUMAN (1-1390): 0: 1283: 100.00
+	Hs
		431764 HS90A_HUMAN (1-732): 0: 1087: 100.00		RON_HUMAN (23-1390): 0: 934: 32.70
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (584-1379): 1.09e-179: 561: 18.13
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (555-1389): 3.08e-175: 549: 17.20
+	Hs
		431591 HS90A_HUMAN (1-732): 0: 1087: 100.00		TIE1_HUMAN (519-1343): 8.72e-158: 508: 20.00
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (597-1389): 2.34e-158: 505: 18.76
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (982-1360): 5.32e-108: 363: 31.83
+	Hs
		431788 HS90A_HUMAN (1-732): 0: 1087: 100.00		MERTK_HUMAN (1057-1385): 1.56e-67: 249: 40.88
+	Hs
		431568 HS90A_HUMAN (1-732): 0: 1087: 100.00		UFO_HUMAN (1078-1333): 5.27e-66: 243: 45.90
+	Hs
		431770 HS90A_HUMAN (1-732): 0: 1087: 100.00		TYRO3_HUMAN (1053-1341): 6.19e-65: 240: 41.67
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		431488 HS90A_HUMAN (1-732): 0: 1087: 100.00		INSRR_HUMAN (1056-1337): 6.24e-54: 209: 39.67
+	Hs
		431871 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB4_HUMAN (1082-1338): 4.97e-52: 203: 42.75
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		431507 HS90A_HUMAN (1-732): 0: 1087: 100.00		FER_HUMAN (1078-1340): 5.99e-52: 199: 37.36
+	Hs
		431619 HS90A_HUMAN (1-732): 0: 1087: 100.00		CSK_HUMAN (1082-1340): 5.46e-52: 192: 40.77
+	Hs
		435497 HS90B_HUMAN (19-732): 0: 1059: 86.13		IGF1R_HUMAN (1084-1337): 2.07e-56: 217: 42.16
+	Hs
		437855 HS90B_HUMAN (19-732): 0: 1059: 86.13		INSRR_HUMAN (1056-1337): 6.24e-54: 209: 39.67
+	Hs
		337314 HS90B_HUMAN (19-732): 0: 1059: 86.13		ABL1_HUMAN (1084-1341): 1.06e-51: 201: 41.38
+	Hs
		437867 HS90B_HUMAN (19-732): 0: 1059: 86.13		FER_HUMAN (1078-1340): 5.99e-52: 199: 37.36