HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	33961781, 35384245, 22939624
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1297
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (9-1265): 0: 1222: 55.39
+	Hs
		435497 HS90B_HUMAN (19-732): 0: 1059: 86.13		IGF1R_HUMAN (9-1265): 0: 1222: 55.39
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (453-1255): 0: 617: 21.02
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (455-1277): 0: 616: 20.88
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (455-1279): 0: 609: 20.55
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20
+	Hs
		171280 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91
+	Hs
		431531 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA1_HUMAN (657-1279): 2.19e-159: 505: 23.51
+	Hs
		171281 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91
+	Hs
		432361 HS90A_HUMAN (1-732): 0: 1087: 100.00		ALK_HUMAN (946-1247): 1.07e-70: 263: 43.46
+	Hs
		431901 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK2_HUMAN (957-1253): 1.12e-67: 247: 42.43
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61
+	Hs
		384111 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91
+	Hs
		431892 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK3_HUMAN (957-1242): 2.05e-62: 231: 40.84
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61
+	Hs
		384122 HS90B_HUMAN (19-732): 0: 1059: 86.13		NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91
+	Hs
		431532 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB3_HUMAN (2-296): 3.16e-34: 145: 18.24
+	Rn
		948940 HS90A_RAT (1-732): 0: 1085: 97.95		Q8K3F9_RAT (28-304): 1.94e-27: 123: 20.19
+	Hs
		431871 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB4_HUMAN (342-482): 7.06e-15: 82.4: 19.73