HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24189400, 22939624
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016323 - basolateral plasma membrane GO:0016324 - apical plasma membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 1342
+	Hs
		431871 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Rn
		948940 HS90A_RAT (1-732): 0: 1085: 97.95		Q8K3F9_RAT (10-1222): 0: 1082: 39.44
+	Hs
		383537 HS90A_HUMAN (1-732): 0: 1087: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Rn
		948941 HS90A_RAT (1-732): 0: 1085: 97.95		Q9QX70_RAT (24-1145): 0: 1054: 43.41
+	Hs
		337788 HS90A_HUMAN (1-732): 0: 1087: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		431749 HS90A_HUMAN (1-732): 0: 1087: 100.00		ROR1_HUMAN (490-1147): 1.55e-126: 416: 17.37
+	Hs
		431435 HS90A_HUMAN (1-732): 0: 1087: 100.00		RET_HUMAN (518-1072): 1.47e-118: 399: 21.15
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (644-993): 1.32e-118: 396: 27.87
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (665-996): 4.18e-104: 356: 29.40
+	Hs
		431848 HS90A_HUMAN (1-732): 0: 1087: 100.00		FAK2_HUMAN (673-1201): 9.77e-104: 355: 25.96
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		431776 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACK1_HUMAN (683-961): 1.22e-46: 184: 38.73
+	Hs
		431626 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL2_HUMAN (705-971): 7.69e-43: 173: 36.06
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (691-978): 1.41e-41: 168: 34.13
+	Hs
		431765 HS90A_HUMAN (1-732): 0: 1087: 100.00		FAK1_HUMAN (713-992): 4.43e-41: 167: 32.19
+	Gg
		94460 HS90B_CHICK (1-732): 0: 1072: 84.04		KSYK_CHICK (715-958): 2e-43: 170: 36.80
+	Gg
		94431 HS90A_CHICK (1-732): 0: 1061: 95.22		KSYK_CHICK (715-958): 2e-43: 170: 36.80
+	Hs
		431488 HS90A_HUMAN (1-732): 0: 1087: 100.00		INSRR_HUMAN (329-644): 4.31e-16: 86.4: 14.51