HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	22939624, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 976
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (24-976): 0: 1111: 51.19
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (27-973): 0: 1106: 47.26
+	Hs
		431531 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Hs
		437892 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHA1_HUMAN (17-967): 0: 959: 49.38
+	Hs
		171280 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB6_HUMAN (28-962): 0: 871: 37.66
+	Hs
		171281 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHB6_HUMAN (28-962): 0: 871: 37.66
+	Hs
		431488 HS90A_HUMAN (1-732): 0: 1087: 100.00		INSRR_HUMAN (287-911): 2.3e-146: 470: 27.55
+	Hs
		431788 HS90A_HUMAN (1-732): 0: 1087: 100.00		MERTK_HUMAN (270-900): 9.58e-146: 460: 23.90
+	Hs
		431568 HS90A_HUMAN (1-732): 0: 1087: 100.00		UFO_HUMAN (294-911): 1.98e-146: 459: 24.49
+	Hs
		437855 HS90B_HUMAN (19-732): 0: 1059: 86.13		INSRR_HUMAN (287-911): 2.3e-146: 470: 27.55
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		435497 HS90B_HUMAN (19-732): 0: 1059: 86.13		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		431445 HS90A_HUMAN (1-732): 0: 1087: 100.00		HCK_HUMAN (591-880): 1.46e-65: 231: 42.12
+	Hs
		431434 HS90A_HUMAN (1-732): 0: 1087: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		431627 HS90A_HUMAN (1-732): 0: 1087: 100.00		FRK_HUMAN (525-864): 4.94e-64: 226: 37.46
+	Rn
		948934 HS90A_RAT (1-732): 0: 1085: 97.95		LYN_RAT (607-879): 1.29e-64: 228: 42.91
+	Hs
		437817 HS90B_HUMAN (19-732): 0: 1059: 86.13		HCK_HUMAN (591-880): 1.46e-65: 231: 42.12
+	Hs
		433526 HS90B_HUMAN (19-732): 0: 1059: 86.13		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91