HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 29311840, 29139175, 25714412, 12586360, 21767636, 22504172, 31980649, 15843522, 10995457, 32707033, 12176997, 16027165, unassigned2173
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains HSP90~Pkinase
Common GO terms GO:0001934 - positive regulation of protein phosphorylation
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 10 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 732
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024