HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: GRK4 (P32298)
G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)
Gene: GRK4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 578
+	Hs
		431631 HS90A_HUMAN (1-732): 0: 1087: 100.00		GRK6_HUMAN (1-577): 0: 524: 65.34
+	Hs
		431584 HS90A_HUMAN (1-732): 0: 1087: 100.00		GRK5_HUMAN (1-561): 1.67e-173: 506: 67.91
+	Hs
		431762 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCT_HUMAN (7-511): 5.23e-146: 439: 23.40
+	Hs
		431550 HS90A_HUMAN (1-732): 0: 1087: 100.00		ARBK1_HUMAN (2-547): 1.25e-145: 437: 34.41
+	Hs
		432101 HS90A_HUMAN (1-732): 0: 1087: 100.00		GRK7_HUMAN (3-543): 1.65e-144: 430: 46.06
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (142-518): 5.03e-143: 424: 30.87
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (143-499): 1.59e-142: 422: 33.24
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (149-518): 3.32e-142: 422: 31.38
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (142-518): 2.26e-143: 424: 30.87
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (142-518): 1.82e-143: 425: 30.87
+	Hs
		431511 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCA_HUMAN (148-501): 2.51e-143: 420: 29.10
+	Hs
		431538 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCB_HUMAN (148-501): 3.06e-142: 417: 29.66
+	Hs
		70435 HS90A_HUMAN (1-732): 0: 1087: 100.00		B2RB89_HUMAN (148-501): 3.06e-142: 417: 29.66
+	Hs
		431537 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCG_HUMAN (148-501): 7.06e-141: 413: 27.97
+	Hs
		431767 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCD_HUMAN (176-468): 5.86e-59: 210: 40.34
+	Hs
		431510 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCA_HUMAN (187-468): 7.65e-57: 204: 39.44
+	Hs
		431548 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCL_HUMAN (185-468): 1.44e-56: 203: 39.72
+	Hs
		408527 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCB_HUMAN (187-468): 2.08e-56: 202: 39.44
+	Mm
		432407 HS90A_MOUSE (1-732): 0: 1083: 97.82		KPCD_MOUSE (176-468): 4.81e-57: 204: 39.66
+	Rn
		448409 HS90A_RAT (1-732): 0: 1085: 97.95		KPCD_RAT (174-468): 4.84e-56: 202: 39.06