HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: VGFR2 (P35968)
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)
Gene: KDR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12820653
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 1356
+	Hs
		431450 HS90A_HUMAN (1-732): 0: 1087: 100.00		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		437821 HS90B_HUMAN (19-732): 0: 1059: 86.13		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (1-213): 3.21e-30: 131: 12.83
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (1-213): 3.21e-30: 131: 12.83
+	Hs
		431600 HS90A_HUMAN (1-732): 0: 1087: 100.00		FLT3_HUMAN (40-555): 7.17e-20: 98.5: 16.22
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (1-120): 8.75e-18: 91.6: 16.90
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		431534 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Hs
		426974 HS90A_HUMAN (1-732): 0: 1087: 100.00		CSF1R_HUMAN (458-975): 2.36e-14: 80.4: 10.19
+	Hs
		431595 HS90A_HUMAN (1-732): 0: 1087: 100.00		VGFR3_HUMAN (1-123): 1.31e-13: 78.1: 14.93
+	Hs
		437897 HS90B_HUMAN (19-732): 0: 1059: 86.13		FGFR3_HUMAN (1-120): 8.75e-18: 91.6: 16.90
+	Hs
		437838 HS90B_HUMAN (19-732): 0: 1059: 86.13		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		437895 HS90B_HUMAN (19-732): 0: 1059: 86.13		FGFR4_HUMAN (538-817): 2.68e-15: 83.5: 14.42
+	Hs
		426977 HS90B_HUMAN (19-732): 0: 1059: 86.13		CSF1R_HUMAN (458-975): 2.36e-14: 80.4: 10.19
+	Hs
		437949 HS90B_HUMAN (19-732): 0: 1059: 86.13		VGFR3_HUMAN (1-123): 1.31e-13: 78.1: 14.93
+	Hs
		499223 ENPL_HUMAN (14-701): 0: 898: 46.78		KIT_HUMAN (15-545): 5.99e-49: 192: 17.46
+	Hs
		508043 H90B3_HUMAN (19-732): 0: 728: 65.41		FGFR1_HUMAN (1-169): 8.34e-17: 88.1: 13.54
+	Hs
		452437 H90B4_HUMAN (30-604): 0: 571: 62.61		PGFRB_HUMAN (33-555): 3.92e-53: 205: 18.45