HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18394702
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0042981 - regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 993
+	Hs
		426974 HS90A_HUMAN (1-732): 0: 1087: 100.00		CSF1R_HUMAN (66-949): 0: 588: 31.11
+	Hs
		426977 HS90B_HUMAN (19-732): 0: 1059: 86.13		CSF1R_HUMAN (66-949): 0: 588: 31.11
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (249-976): 5.93e-163: 506: 14.96
+	Hs
		431591 HS90A_HUMAN (1-732): 0: 1087: 100.00		TIE1_HUMAN (62-958): 3.29e-156: 493: 18.92
+	Hs
		438028 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHB1_HUMAN (249-976): 5.93e-163: 506: 14.96
+	Hs
		437946 HS90B_HUMAN (19-732): 0: 1059: 86.13		TIE1_HUMAN (62-958): 3.29e-156: 493: 18.92
+	Hs
		499223 ENPL_HUMAN (14-701): 0: 898: 46.78		KIT_HUMAN (57-986): 0: 594: 30.44
+	Hs
		431596 HS90A_HUMAN (1-732): 0: 1087: 100.00		VGFR2_HUMAN (55-536): 9.06e-33: 139: 14.02
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (6-354): 1.85e-28: 125: 11.62
+	Hs
		431595 HS90A_HUMAN (1-732): 0: 1087: 100.00		VGFR3_HUMAN (70-533): 8.45e-27: 120: 14.15
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (20-260): 5.2e-21: 101: 9.09
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (6-354): 1.85e-28: 125: 11.62
+	Hs
		437949 HS90B_HUMAN (19-732): 0: 1059: 86.13		VGFR3_HUMAN (70-533): 8.45e-27: 120: 14.15
+	Hs
		431534 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR4_HUMAN (47-355): 1.59e-17: 89.8: 11.67
+	Hs
		437838 HS90B_HUMAN (19-732): 0: 1059: 86.13		FGFR1_HUMAN (6-360): 2.83e-24: 111: 10.90
+	Hs
		437897 HS90B_HUMAN (19-732): 0: 1059: 86.13		FGFR3_HUMAN (20-260): 5.2e-21: 101: 9.09
+	Hs
		431450 HS90A_HUMAN (1-732): 0: 1087: 100.00		PGFRB_HUMAN (16-230): 1.69e-09: 64: 15.04
+	Hs
		437895 HS90B_HUMAN (19-732): 0: 1059: 86.13		FGFR4_HUMAN (47-355): 1.59e-17: 89.8: 11.67
+	Hs
		437821 HS90B_HUMAN (19-732): 0: 1059: 86.13		PGFRB_HUMAN (16-230): 1.69e-09: 64: 15.04