HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27684187
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 347
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (36-345): 7.41e-128: 376: 20.76
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (36-345): 5.46e-128: 376: 20.76
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (38-345): 6.46e-126: 371: 22.79
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (24-345): 1.36e-125: 370: 20.91
+	Hs
		431752 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89
+	Hs
		431548 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCL_HUMAN (22-344): 3.41e-119: 360: 19.58
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (36-345): 5.46e-128: 376: 20.76
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (36-345): 1.63e-128: 378: 21.38
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43
+	Hs
		437907 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCL_HUMAN (22-344): 3.41e-119: 360: 19.58
+	Hs
		153069 HS90A_HUMAN (1-732): 0: 1087: 100.00		MP2K7_HUMAN (49-345): 3.41e-108: 324: 43.81
+	Hs
		431792 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK4_HUMAN (42-345): 1.62e-103: 314: 33.12
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43
+	Hs
		153070 HS90B_HUMAN (19-732): 0: 1059: 86.13		MP2K7_HUMAN (49-345): 3.41e-108: 324: 43.81
+	Hs
		160336 HS90A_HUMAN (1-732): 0: 1087: 100.00		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		160340 HS90B_HUMAN (19-732): 0: 1059: 86.13		AURKA_HUMAN (1-334): 5.44e-97: 294: 24.70
+	Hs
		431806 HS90A_HUMAN (1-732): 0: 1087: 100.00		MP2K5_HUMAN (56-324): 7.89e-66: 216: 45.09
+	Hs
		431753 HS90A_HUMAN (1-732): 0: 1087: 100.00		MP2K1_HUMAN (49-344): 5.25e-65: 212: 36.69
+	Hs
		431598 HS90A_HUMAN (1-732): 0: 1087: 100.00		MP2K2_HUMAN (49-343): 4.4e-63: 207: 35.78