HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	31980649, 22939624, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 740
+	Hs
		431876 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		432343 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A6_HUMAN (1-740): 0: 771: 76.54
+	Hs
		270363 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A5_HUMAN (47-734): 0: 703: 40.86
+	Hs
		270364 HS90B_HUMAN (19-732): 0: 1059: 86.13		KS6A5_HUMAN (47-734): 0: 703: 40.86
+	Hs
		272843 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A4_HUMAN (59-739): 0: 646: 40.81
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (327-739): 1.82e-126: 387: 21.76
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (413-739): 6.38e-126: 385: 24.50
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (390-739): 1.18e-124: 382: 22.37
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (327-739): 6.45e-126: 385: 21.02
+	Hs
		432326 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6B2_HUMAN (419-727): 5.97e-118: 364: 29.66
+	Hs
		431542 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6B1_HUMAN (397-727): 8.14e-116: 361: 25.50
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (327-739): 6.45e-126: 385: 21.02
+	Hs
		431511 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (413-739): 5.92e-126: 385: 24.78
+	Hs
		431538 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCB_HUMAN (409-714): 3.04e-116: 355: 29.15
+	Hs
		70435 HS90A_HUMAN (1-732): 0: 1087: 100.00		B2RB89_HUMAN (409-714): 3.04e-116: 355: 29.15
+	Hs
		431873 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02
+	Hs
		116956 HS90A_HUMAN (1-732): 0: 1087: 100.00		SGK1_HUMAN (428-724): 5.73e-27: 116: 29.36
+	Hs
		116958 HS90B_HUMAN (19-732): 0: 1059: 86.13		SGK1_HUMAN (428-724): 5.73e-27: 116: 29.36