HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

The method score is based on:

Property	Details
Experiments	15001357, 20540933, 15001356, 24147044
Identification Methods	unspecified method, affinity chromatography technology, pull down, biochemical
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 6 others more... GO:0009410 - response to xenobiotic stimulus GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0042220 - response to cocaine GO:0046677 - response to antibiotic GO:0097718 - disordered domain specific binding
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	732
Hs

1	491

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024