Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1
Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.992 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24462205, 26496610, 26804907, 22504172, 27353360, 25486457, 14718169, 21745565, 33961781, 29743370, 20159553, 22315411, 22729780, 19875381, 21360678, 24189400, 12930845, 11413142, 24292678, 16335536 and 8 others
more... |
| Identification Methods | affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation, tandem affinity purification, coimmunoprecipitation, anti bait coimmunoprecipitation, luminescence based mammalian interactome mapping |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CDC37_M~HSP90, CDC37_N~HSP90 |
| Common GO terms | GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006457 - protein folding GO:0050821 - protein stabilization GO:0051082 - unfolded protein binding and 2 others more... |
| Homologous interactions | 14 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
