HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: M3K11 (Q16584)
Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase)
Gene: MAP3K11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15001580, 24912674
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0016020 - membrane GO:0042803 - protein homodimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 847
+	Hs
		438211 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K11_HUMAN (1-847): 0: 649: 100.00
+	Hs
		431735 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K9_HUMAN (44-825): 5.7e-161: 499: 46.37
+	Hs
		431754 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K10_HUMAN (38-840): 6.34e-155: 479: 44.59
+	Hs
		438073 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K9_HUMAN (44-825): 5.7e-161: 499: 46.37
+	Hs
		438088 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K10_HUMAN (38-840): 6.34e-155: 479: 44.59
+	Hs
		431947 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K21_HUMAN (45-830): 8.33e-141: 445: 46.01
+	Hs
		438255 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K21_HUMAN (45-830): 8.33e-141: 445: 46.01
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (31-847): 1.28e-120: 393: 20.94
+	Hs
		431787 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K12_HUMAN (58-810): 3.8e-123: 393: 26.28
+	Hs
		431776 HS90A_HUMAN (1-732): 0: 1087: 100.00		ACK1_HUMAN (61-847): 1.02e-118: 386: 20.77
+	Hs
		337314 HS90B_HUMAN (19-732): 0: 1059: 86.13		ABL1_HUMAN (31-847): 1.28e-120: 393: 20.94
+	Hs
		438113 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K12_HUMAN (58-810): 3.8e-123: 393: 26.28
+	Hs
		438103 HS90B_HUMAN (19-732): 0: 1059: 86.13		ACK1_HUMAN (61-847): 1.02e-118: 386: 20.77
+	Hs
		431627 HS90A_HUMAN (1-732): 0: 1087: 100.00		FRK_HUMAN (113-377): 1.3e-100: 323: 34.06
+	Hs
		437967 HS90B_HUMAN (19-732): 0: 1059: 86.13		FRK_HUMAN (113-377): 1.3e-100: 323: 34.06
+	Zm
		8229 A0A1D6LMW9_MAIZE (4-704): 0: 843: 46.30		A0A1D6ELX5_MAIZE (111-390): 2.11e-103: 338: 35.66
+	Hs
		992583 H90B3_HUMAN (19-732): 0: 728: 65.41		ACK1_HUMAN (61-847): 1.02e-118: 386: 20.77