HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.766

The method score is based on:

Property Details
Experiments 26517842, 14764593, 24844779, 17442277, 9079689, 17237281, 20724477, 21413014, 15319539, 20668552, 19491109, 25204544, 24648344, 33550096, 16951198, 16507982, 15147973, 14726529, 17244529, 18538669 and 1 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, surface plasmon resonance
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0031625 - ubiquitin protein ligase binding
and 3 others

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Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 732
Hs

1 826
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+ Mm
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+ Mm
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+ Rn
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+ Mm
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+ Dm

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Last updated: 15 Jul 2024