HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: DDR2 (Q16832)
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Gene: DDR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	22939624, 35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 855
+	Hs
		431779 HS90A_HUMAN (1-732): 0: 1087: 100.00		DDR1_HUMAN (22-849): 0: 655: 52.08
+	Hs
		431901 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK2_HUMAN (498-850): 2.17e-106: 348: 40.50
+	Hs
		431472 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49
+	Hs
		384111 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		431536 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR3_HUMAN (485-851): 5.88e-101: 333: 31.28
+	Hs
		431892 HS90A_HUMAN (1-732): 0: 1087: 100.00		NTRK3_HUMAN (551-849): 3.61e-99: 329: 42.63
+	Hs
		169159 HS90A_HUMAN (1-732): 0: 1087: 100.00		MUSK_HUMAN (557-854): 3.25e-98: 327: 39.42
+	Hs
		431534 HS90A_HUMAN (1-732): 0: 1087: 100.00		FGFR4_HUMAN (537-849): 4.35e-98: 325: 34.78
+	Hs
		411945 HS90A_HUMAN (1-732): 0: 1087: 100.00		FYN_HUMAN (548-850): 3.85e-99: 320: 35.64
+	Hs
		431433 HS90A_HUMAN (1-732): 0: 1087: 100.00		YES_HUMAN (556-850): 2.32e-97: 316: 34.58
+	Hs
		431481 HS90A_HUMAN (1-732): 0: 1087: 100.00		SRC_HUMAN (521-850): 1.38e-97: 316: 31.52
+	Hs
		169160 HS90B_HUMAN (19-732): 0: 1059: 86.13		MUSK_HUMAN (557-854): 3.25e-98: 327: 39.42
+	Hs
		431438 HS90A_HUMAN (1-732): 0: 1087: 100.00		IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13
+	Hs
		431749 HS90A_HUMAN (1-732): 0: 1087: 100.00		ROR1_HUMAN (556-849): 2.13e-58: 217: 39.87
+	Hs
		431750 HS90A_HUMAN (1-732): 0: 1087: 100.00		ROR2_HUMAN (551-854): 8.47e-56: 209: 38.39
+	Hs
		337312 HS90A_HUMAN (1-732): 0: 1087: 100.00		ABL1_HUMAN (557-846): 9.71e-55: 207: 41.03
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (554-845): 1.09e-54: 206: 38.93
+	Hs
		431627 HS90A_HUMAN (1-732): 0: 1087: 100.00		FRK_HUMAN (548-845): 2.59e-53: 195: 38.00
+	Hs
		337314 HS90B_HUMAN (19-732): 0: 1059: 86.13		ABL1_HUMAN (557-846): 9.71e-55: 207: 41.03
+	Hs
		69196 HS90B_HUMAN (19-732): 0: 1059: 86.13		A9UEZ6_HUMAN (557-846): 3.99e-54: 206: 41.03