HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: LRRK1 (Q38SD2)
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)
Gene: LRRK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29519959, 32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005525 - GTP binding GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 2015
+	Hs
		438225 HS90B_HUMAN (19-732): 0: 1059: 86.13		LRRK1_HUMAN (1-2015): 0: 1859: 99.60
+	Hs
		431735 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K9_HUMAN (1247-1520): 8.61e-22: 105: 31.60
+	Mm
		432426 HS90A_MOUSE (1-732): 0: 1083: 97.82		LRRK2_MOUSE (47-291): 6.12e-23: 109: 13.73
+	Hs
		431938 HS90A_HUMAN (1-732): 0: 1087: 100.00		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		431754 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K10_HUMAN (1247-1521): 1.17e-20: 101: 32.41
+	Hs
		438073 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K9_HUMAN (1247-1520): 8.61e-22: 105: 31.60
+	Hs
		438251 HS90B_HUMAN (19-732): 0: 1059: 86.13		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65
+	Hs
		438088 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K10_HUMAN (1247-1521): 1.17e-20: 101: 32.41
+	Mm
		435923 ENPL_MOUSE (14-732): 0: 901: 45.07		LRRK2_MOUSE (47-291): 6.12e-23: 109: 13.73
+	Hs
		538262 ENPL_HUMAN (14-701): 0: 898: 46.78		LRRK2_HUMAN (47-285): 1.02e-20: 102: 11.65