HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: ULK3 (Q6PHR2)
Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)
Gene: ULK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 472
+	Hs
		438277 HS90B_HUMAN (19-732): 0: 1059: 86.13		ULK3_HUMAN (1-472): 1.03e-152: 444: 100.00
+	Hs
		431826 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2G_HUMAN (1-461): 1.28e-139: 414: 20.69
+	Hs
		431827 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2D_HUMAN (1-352): 1.81e-134: 398: 25.68
+	Hs
		438147 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2G_HUMAN (1-461): 1.28e-139: 414: 20.69
+	Hs
		438148 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2D_HUMAN (1-352): 1.81e-134: 398: 25.68
+	Hs
		432166 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC1G_HUMAN (14-345): 1.69e-121: 364: 32.25
+	Hs
		438441 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC1G_HUMAN (14-345): 1.69e-121: 364: 32.25
+	Hs
		262219 HS90A_HUMAN (1-732): 0: 1087: 100.00		ULK1_HUMAN (4-271): 1.85e-49: 183: 39.93
+	Mm
		250790 HS90A_MOUSE (1-732): 0: 1083: 97.82		ULK1_MOUSE (14-271): 3.23e-50: 186: 40.38
+	Hs
		160336 HS90A_HUMAN (1-732): 0: 1087: 100.00		AURKA_HUMAN (11-270): 2.18e-45: 164: 35.25
+	Zm
		24080 A0A1D6LMW9_MAIZE (4-704): 0: 843: 46.30		A0A1D6ICZ3_MAIZE (14-423): 8.38e-138: 408: 21.07
+	Hs
		432294 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK36_HUMAN (11-282): 1.17e-42: 164: 37.72
+	Hs
		262221 HS90B_HUMAN (19-732): 0: 1059: 86.13		ULK1_HUMAN (4-271): 1.85e-49: 183: 39.93
+	Zm
		35496 A0A1D6LMW9_MAIZE (4-704): 0: 843: 46.30		A0A1D6QH07_MAIZE (8-404): 6.61e-130: 385: 24.25
+	Hs
		160340 HS90B_HUMAN (19-732): 0: 1059: 86.13		AURKA_HUMAN (11-270): 2.18e-45: 164: 35.25
+	Sc
		544106 HSC82_YEAST (16-732): 0: 902: 59.39		ATG1_YEAST (18-271): 4.45e-53: 193: 39.47
+	Hs
		1123413 H90B4_HUMAN (30-604): 0: 571: 62.61		ULK3_HUMAN (1-472): 1.03e-152: 444: 100.00