HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: KSR2 (Q6VAB6)
Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
Gene: KSR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	32707033, 22939624, 25036637
Identification Methods	affinity chromatography technology, pull down, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 950
+	Rn
		88624 HS90A_RAT (1-732): 0: 1085: 97.95		D3ZHL1_RAT (19-949): 0: 585: 46.52
+	Hs
		431692 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA4_HUMAN (79-949): 0: 571: 14.24
+	Hs
		431562 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA3_HUMAN (88-939): 0: 567: 14.56
+	Hs
		431691 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHB1_HUMAN (79-939): 0: 556: 13.50
+	Hs
		431561 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA2_HUMAN (112-950): 2.48e-173: 531: 15.49
+	Hs
		431531 HS90A_HUMAN (1-732): 0: 1087: 100.00		EPHA1_HUMAN (125-950): 2.7e-159: 495: 14.54
+	Hs
		431764 HS90A_HUMAN (1-732): 0: 1087: 100.00		RON_HUMAN (78-935): 2.46e-145: 468: 16.94
+	Hs
		437892 HS90B_HUMAN (19-732): 0: 1059: 86.13		EPHA1_HUMAN (125-950): 2.7e-159: 495: 14.54
+	Hs
		432033 HS90A_HUMAN (1-732): 0: 1087: 100.00		KSR1_HUMAN (18-950): 4.63e-144: 453: 40.02
+	Hs
		431444 HS90A_HUMAN (1-732): 0: 1087: 100.00		MET_HUMAN (88-934): 2.77e-134: 438: 14.43
+	Mm
		432406 HS90A_MOUSE (1-732): 0: 1083: 97.82		BRAF_MOUSE (284-942): 7.45e-137: 429: 22.01
+	Hs
		431496 HS90A_HUMAN (1-732): 0: 1087: 100.00		BRAF_HUMAN (325-942): 1.44e-134: 423: 22.19
+	Hs
		437816 HS90B_HUMAN (19-732): 0: 1059: 86.13		MET_HUMAN (88-934): 2.77e-134: 438: 14.43
+	Hs
		373543 HS90A_HUMAN (1-732): 0: 1087: 100.00		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		432156 HS90A_HUMAN (1-732): 0: 1087: 100.00		Q96II5_HUMAN (321-949): 2.47e-128: 402: 22.27
+	Hs
		431459 HS90A_HUMAN (1-732): 0: 1087: 100.00		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12
+	Hs
		437860 HS90B_HUMAN (19-732): 0: 1059: 86.13		BRAF_HUMAN (325-942): 1.44e-134: 423: 22.19
+	Gg
		513713 HS90A_CHICK (1-732): 0: 1061: 95.22		BRAF_CHICK (324-942): 1.32e-131: 416: 22.62
+	Hs
		373549 HS90B_HUMAN (19-732): 0: 1059: 86.13		RAF1_HUMAN (304-945): 1.34e-129: 407: 22.49
+	Hs
		437832 HS90B_HUMAN (19-732): 0: 1059: 86.13		ARAF_HUMAN (321-949): 4.2e-127: 399: 22.12