HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: PIWL4 (Q7Z3Z4)
Piwi-like protein 4
Gene: PIWIL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005739 - mitochondrion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 852
+	Hs
		432159 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIWL1_HUMAN (15-852): 0: 977: 49.23
+	Hs
		432355 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO2_HUMAN (90-845): 0: 915: 21.78
+	Mm
		432448 HS90A_MOUSE (1-732): 0: 1083: 97.82		AGO2_MOUSE (79-845): 0: 916: 21.49
+	Hs
		432356 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO1_HUMAN (88-837): 0: 902: 21.89
+	Hs
		432271 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO3_HUMAN (84-845): 0: 900: 21.03
+	Hs
		432088 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIWL2_HUMAN (2-852): 0: 898: 35.10
+	Mm
		1174807 Q71LX8_MOUSE (19-732): 0: 1063: 86.98		AGO2_MOUSE (79-845): 0: 916: 21.49
+	Hs
		438614 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO2_HUMAN (90-845): 0: 915: 21.78
+	Hs
		432278 HS90A_HUMAN (1-732): 0: 1087: 100.00		AGO4_HUMAN (82-844): 0: 883: 20.81
+	Hs
		438615 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO1_HUMAN (88-837): 0: 902: 21.89
+	Hs
		438537 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO3_HUMAN (84-845): 0: 900: 21.03
+	Hs
		438545 HS90B_HUMAN (19-732): 0: 1059: 86.13		AGO4_HUMAN (82-844): 0: 883: 20.81
+	Dm
		365460 HSP83_DROME (15-732): 0: 1034: 78.41		Q32KD4_DROME (9-837): 0: 902: 19.65
+	At
		138329 HS903_ARATH (15-732): 0: 981: 67.96		AGO1_ARATH (8-846): 0: 934: 19.62
+	Dm
		365480 HSP83_DROME (15-732): 0: 1034: 78.41		PIWI_DROME (18-852): 0: 783: 32.90
+	Dm
		365462 HSP83_DROME (15-732): 0: 1034: 78.41		AGO3_DROME (60-852): 0: 779: 34.76
+	Dm
		365485 HSP83_DROME (15-732): 0: 1034: 78.41		AGO2_DROME (98-837): 0: 617: 20.95
+	Hs
		1123461 H90B3_HUMAN (19-732): 0: 728: 65.41		AGO3_HUMAN (84-845): 0: 900: 21.03
+	Hs
		1123440 H90B4_HUMAN (30-604): 0: 571: 62.61		AGO3_HUMAN (84-845): 0: 900: 21.03
+	Hs
		1123442 H90B4_HUMAN (30-604): 0: 571: 62.61		AGO4_HUMAN (82-844): 0: 883: 20.81