HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: PIM3 (Q86V86)
Serine/threonine-protein kinase pim-3 (EC 2.7.11.1)
Gene: PIM3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 326
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (11-323): 4.07e-126: 371: 23.71
+	Hs
		431471 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIM1_HUMAN (1-313): 2.27e-126: 365: 69.21
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (11-323): 2.69e-123: 363: 23.03
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (27-323): 2.57e-123: 363: 23.00
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (11-323): 6.61e-124: 365: 22.73
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (11-323): 5.31e-124: 365: 22.73
+	Hs
		431511 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCA_HUMAN (28-325): 2.63e-123: 359: 24.36
+	Hs
		431538 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCB_HUMAN (28-325): 3.41e-122: 356: 24.36
+	Hs
		70435 HS90A_HUMAN (1-732): 0: 1087: 100.00		B2RB89_HUMAN (28-325): 3.41e-122: 356: 24.36
+	Hs
		431537 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCG_HUMAN (30-325): 7.09e-122: 355: 26.13
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (11-323): 5.31e-124: 365: 22.73
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (11-323): 2.37e-125: 368: 23.33
+	Hs
		437837 HS90B_HUMAN (19-732): 0: 1059: 86.13		PIM1_HUMAN (1-313): 2.27e-126: 365: 69.21
+	Hs
		432314 HS90A_HUMAN (1-732): 0: 1087: 100.00		PIM2_HUMAN (31-305): 9.18e-115: 336: 63.41
+	Hs
		437870 HS90B_HUMAN (19-732): 0: 1059: 86.13		KAPCA_HUMAN (28-325): 2.63e-123: 359: 24.36
+	Hs
		437900 HS90B_HUMAN (19-732): 0: 1059: 86.13		KAPCB_HUMAN (28-325): 3.41e-122: 356: 24.36
+	Hs
		437898 HS90B_HUMAN (19-732): 0: 1059: 86.13		KAPCG_HUMAN (30-325): 7.09e-122: 355: 26.13
+	Hs
		432176 HS90A_HUMAN (1-732): 0: 1087: 100.00		PASK_HUMAN (4-293): 2.22e-34: 135: 34.31
+	Hs
		432249 HS90A_HUMAN (1-732): 0: 1087: 100.00		NUAK2_HUMAN (33-293): 1.99e-32: 128: 32.96
+	Hs
		432168 HS90A_HUMAN (1-732): 0: 1087: 100.00		TSSK2_HUMAN (37-293): 7.42e-33: 126: 32.84