HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: MYLK4 (Q86YV6)
Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085)
Gene: MYLK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

Property	Details
Experiments	26186194, 28514442, 33961781, 32707033, 22939624
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 388
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (10-380): 4.47e-137: 401: 22.86
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (7-386): 4.81e-135: 396: 23.02
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (3-386): 2.96e-134: 394: 23.68
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (3-386): 3.87e-135: 396: 23.68
+	Hs
		431913 HS90A_HUMAN (1-732): 0: 1087: 100.00		MYLK3_HUMAN (27-378): 3.38e-129: 392: 60.80
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (3-386): 4.91e-135: 396: 23.68
+	Hs
		432166 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC1G_HUMAN (93-384): 4.51e-127: 376: 33.56
+	Hs
		432254 HS90A_HUMAN (1-732): 0: 1087: 100.00		MYLK2_HUMAN (30-388): 3.9e-124: 372: 50.69
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (3-386): 4.91e-135: 396: 23.68
+	Hs
		431538 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCB_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		70435 HS90A_HUMAN (1-732): 0: 1087: 100.00		B2RB89_HUMAN (85-383): 5.94e-127: 371: 23.45
+	Hs
		431827 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2D_HUMAN (104-370): 3.52e-124: 369: 35.06
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (6-386): 1.66e-135: 397: 23.86
+	Hs
		431682 HS90A_HUMAN (1-732): 0: 1087: 100.00		DAPK1_HUMAN (96-361): 1.14e-73: 251: 44.89
+	Hs
		200082 HS90A_HUMAN (1-732): 0: 1087: 100.00		DAPK3_HUMAN (94-361): 2.46e-71: 232: 43.48
+	Hs
		200083 HS90B_HUMAN (19-732): 0: 1059: 86.13		DAPK3_HUMAN (94-361): 2.46e-71: 232: 43.48
+	Hs
		431475 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPSH1_HUMAN (84-361): 1e-54: 187: 38.25
+	Hs
		432175 HS90A_HUMAN (1-732): 0: 1087: 100.00		PSKH2_HUMAN (111-361): 3.66e-53: 182: 38.19
+	Hs
		432373 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2A_HUMAN (110-362): 3.53e-50: 177: 37.35
+	Hs
		437842 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPSH1_HUMAN (84-361): 1e-54: 187: 38.25