HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: STK35 (Q8TDR2)
Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1)
Gene: STK35

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 32707033
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 534
+	Hs
		432048 HS90A_HUMAN (1-732): 0: 1087: 100.00		PDK1L_HUMAN (197-530): 1.73e-128: 380: 67.85
+	Hs
		431510 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCA_HUMAN (17-532): 1.16e-118: 366: 15.47
+	Hs
		438385 HS90B_HUMAN (19-732): 0: 1059: 86.13		STK35_HUMAN (1-523): 3.69e-130: 391: 100.00
+	Hs
		408527 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCB_HUMAN (17-530): 4.59e-114: 354: 15.34
+	Hs
		438344 HS90B_HUMAN (19-732): 0: 1059: 86.13		PDK1L_HUMAN (197-530): 1.73e-128: 380: 67.85
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (199-533): 8.42e-115: 343: 22.86
+	Hs
		437869 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCA_HUMAN (17-532): 1.16e-118: 366: 15.47
+	Hs
		408529 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCB_HUMAN (17-530): 4.59e-114: 354: 15.34
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (199-533): 8.42e-115: 343: 22.86
+	Hs
		431672 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A3_HUMAN (146-532): 1.13e-93: 303: 18.50
+	Hs
		431873 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A2_HUMAN (182-532): 8.8e-94: 303: 20.11
+	Hs
		431876 HS90A_HUMAN (1-732): 0: 1087: 100.00		KS6A1_HUMAN (154-532): 7.61e-91: 295: 18.93
+	Hs
		438011 HS90B_HUMAN (19-732): 0: 1059: 86.13		KS6A3_HUMAN (146-532): 1.13e-93: 303: 18.50
+	Hs
		438190 HS90B_HUMAN (19-732): 0: 1059: 86.13		KS6A2_HUMAN (182-532): 8.8e-94: 303: 20.11
+	Hs
		438193 HS90B_HUMAN (19-732): 0: 1059: 86.13		KS6A1_HUMAN (154-532): 7.61e-91: 295: 18.93
+	Hs
		432234 HS90A_HUMAN (1-732): 0: 1087: 100.00		STK33_HUMAN (129-523): 2.74e-20: 95.9: 25.78
+	Hs
		431742 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK6_HUMAN (198-521): 1.7e-17: 85.5: 28.20
+	Hs
		438496 HS90B_HUMAN (19-732): 0: 1059: 86.13		STK33_HUMAN (129-523): 2.74e-20: 95.9: 25.78
+	Hs
		438076 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK6_HUMAN (198-521): 1.7e-17: 85.5: 28.20
+	Sp
		383458 HSP90_SCHPO (15-732): 0: 914: 62.08		CDK1_SCHPO (202-520): 2.12e-17: 84.7: 30.03