HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: DYRK2 (Q92630)
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)
Gene: DYRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	19287380, 22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 601
+	Hs
		431549 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		431741 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK3_HUMAN (219-542): 1.22e-134: 396: 27.80
+	Hs
		437908 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK2_HUMAN (219-543): 6.32e-142: 415: 27.71
+	Hs
		431752 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCE_HUMAN (55-510): 3.31e-123: 382: 16.70
+	Hs
		431840 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK13_HUMAN (3-598): 8.85e-117: 381: 19.87
+	Hs
		431762 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCT_HUMAN (56-530): 5.62e-123: 380: 18.30
+	Hs
		432288 HS90A_HUMAN (1-732): 0: 1087: 100.00		DYRK4_HUMAN (119-595): 5.24e-124: 377: 44.24
+	Hs
		414683 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK1_HUMAN (219-538): 9.81e-126: 373: 27.13
+	Hs
		438075 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK3_HUMAN (219-542): 1.22e-134: 396: 27.80
+	Hs
		431548 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPCL_HUMAN (38-510): 5.5e-118: 367: 17.08
+	Hs
		431834 HS90A_HUMAN (1-732): 0: 1087: 100.00		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		432392 HS90A_HUMAN (1-732): 0: 1087: 100.00		DYR1B_HUMAN (149-537): 1.88e-118: 366: 39.11
+	Hs
		438085 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCE_HUMAN (55-510): 3.31e-123: 382: 16.70
+	Hs
		438094 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCT_HUMAN (56-530): 5.62e-123: 380: 18.30
+	Hs
		431743 HS90A_HUMAN (1-732): 0: 1087: 100.00		CDK5_HUMAN (219-541): 2.4e-116: 349: 27.49
+	Hs
		437907 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPCL_HUMAN (38-510): 5.5e-118: 367: 17.08
+	Hs
		438155 HS90B_HUMAN (19-732): 0: 1059: 86.13		DYR1A_HUMAN (211-537): 2.66e-117: 367: 42.52
+	Hs
		438077 HS90B_HUMAN (19-732): 0: 1059: 86.13		CDK5_HUMAN (219-541): 2.4e-116: 349: 27.49
+	Hs
		431655 HS90A_HUMAN (1-732): 0: 1087: 100.00		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56
+	Hs
		437996 HS90B_HUMAN (19-732): 0: 1059: 86.13		CLK2_HUMAN (204-543): 6.41e-57: 201: 31.56