HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: PSKH2 (Q96QS6)
Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2)
Gene: PSKH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.922

Property	Details
Experiments	26186194, 33961781, 32707033, 22939624, 25036637
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 385
+	Hs
		431573 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT2_HUMAN (24-373): 2.46e-136: 399: 27.37
+	Hs
		431827 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2D_HUMAN (58-382): 7.47e-136: 399: 31.50
+	Hs
		432376 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT3_HUMAN (35-373): 1.45e-135: 397: 27.09
+	Hs
		431475 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPSH1_HUMAN (3-355): 4.91e-136: 396: 64.87
+	Rn
		812703 HS90A_RAT (1-732): 0: 1085: 97.95		AKT1_RAT (24-378): 1.91e-134: 394: 26.10
+	Mm
		432411 HS90A_MOUSE (1-732): 0: 1083: 97.82		AKT1_MOUSE (24-378): 1.6e-134: 394: 26.10
+	Hs
		431572 HS90A_HUMAN (1-732): 0: 1087: 100.00		AKT1_HUMAN (35-379): 6.12e-130: 383: 27.68
+	Hs
		432373 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2A_HUMAN (58-382): 5.21e-130: 383: 30.58
+	Hs
		432166 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC1G_HUMAN (63-381): 7.2e-129: 380: 37.61
+	Hs
		431511 HS90A_HUMAN (1-732): 0: 1087: 100.00		KAPCA_HUMAN (52-372): 1.78e-130: 379: 30.09
+	Hs
		437928 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT2_HUMAN (24-373): 2.46e-136: 399: 27.37
+	Mm
		513660 HS90B_MOUSE (19-732): 0: 1063: 86.98		AKT1_MOUSE (24-378): 1.6e-134: 394: 26.10
+	Hs
		437842 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPSH1_HUMAN (3-355): 4.91e-136: 396: 64.87
+	Bt
		964601 HS90B_BOVIN (19-732): 0: 1059: 86.28		AKT1_BOVIN (24-378): 7.25e-135: 395: 26.37
+	Hs
		437927 HS90B_HUMAN (19-732): 0: 1059: 86.13		AKT1_HUMAN (35-379): 6.12e-130: 383: 27.68
+	Hs
		437870 HS90B_HUMAN (19-732): 0: 1059: 86.13		KAPCA_HUMAN (52-372): 1.78e-130: 379: 30.09
+	Hs
		431898 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC4_HUMAN (63-344): 5.4e-68: 223: 41.32
+	Hs
		432065 HS90A_HUMAN (1-732): 0: 1087: 100.00		CAMKV_HUMAN (59-336): 1.29e-61: 207: 40.77
+	Hs
		432057 HS90A_HUMAN (1-732): 0: 1087: 100.00		DCLK2_HUMAN (59-342): 2.84e-59: 206: 39.58
+	Hs
		432028 HS90A_HUMAN (1-732): 0: 1087: 100.00		MYLK4_HUMAN (68-320): 1.45e-53: 183: 38.19