HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: PRPK (Q96S44)
EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)
Gene: TP53RK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 253
+	Hs
		160336 HS90A_HUMAN (1-732): 0: 1087: 100.00		AURKA_HUMAN (1-245): 5.49e-80: 247: 16.06
+	Hs
		431898 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC4_HUMAN (13-233): 2.76e-70: 224: 17.57
+	Hs
		160340 HS90B_HUMAN (19-732): 0: 1059: 86.13		AURKA_HUMAN (1-245): 5.49e-80: 247: 16.06
+	Hs
		438453 HS90B_HUMAN (19-732): 0: 1059: 86.13		PRPK_HUMAN (1-253): 1.74e-77: 236: 100.00
+	Hs
		438210 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC4_HUMAN (13-233): 2.76e-70: 224: 17.57
+	Hs
		432166 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC1G_HUMAN (33-191): 5.57e-26: 107: 17.90
+	Hs
		431475 HS90A_HUMAN (1-732): 0: 1087: 100.00		KPSH1_HUMAN (3-195): 8e-25: 103: 20.41
+	Hs
		431682 HS90A_HUMAN (1-732): 0: 1087: 100.00		DAPK1_HUMAN (26-188): 3.81e-22: 97.1: 19.39
+	Hs
		431827 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2D_HUMAN (28-187): 1.48e-21: 94.8: 18.41
+	Hs
		200082 HS90A_HUMAN (1-732): 0: 1087: 100.00		DAPK3_HUMAN (26-188): 2.64e-21: 94: 21.82
+	Hs
		431826 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2G_HUMAN (28-187): 3.99e-21: 93.7: 18.18
+	Hs
		438441 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC1G_HUMAN (33-191): 5.57e-26: 107: 17.90
+	Hs
		437842 HS90B_HUMAN (19-732): 0: 1059: 86.13		KPSH1_HUMAN (3-195): 8e-25: 103: 20.41
+	Hs
		438148 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2D_HUMAN (28-187): 1.48e-21: 94.8: 18.41
+	Hs
		200083 HS90B_HUMAN (19-732): 0: 1059: 86.13		DAPK3_HUMAN (26-188): 2.64e-21: 94: 21.82
+	Hs
		438147 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2G_HUMAN (28-187): 3.99e-21: 93.7: 18.18
+	Hs
		1083212 H90B3_HUMAN (19-732): 0: 728: 65.41		KCC4_HUMAN (13-233): 2.76e-70: 224: 17.57